Jevtana has side effects similar to Taxotere. Men may also have fluid retention and pain, tingling, or numbness in the fingers or toes. Possible side effects of Taxotere include nausea, hair loss, and lower production of blood cells. When Taxotere stops working, other chemo drugs, such as cabazitaxel ( Jevtana), can help extend survival in some men. D ocetaxel ( Taxotere), when taken with the steroid prednisone, can help extend survival in some men. Only a few chemotherapy medications have been shown to work for advanced prostate cancer. Chemotherapy is another option when hormone therapy stops working.Other common side effects include fatigue, fever, back pain, and nausea. It's used for men with few or no symptoms and when advanced prostate cancer no longer responds to hormone therapy. Provenge is created by taking immune cells from a patient, genetically engineering them to fight prostate cancer, and putting them back into the patient. Most men who take Provenge live at least 2 more years after starting the treatment. If hormone therapy doesn’t slow the growth of the cancer, the next step may be a prostate cancer " vaccine" called sipuleucel-T ( Provenge).The use of medical rather than surgical treatment offers the option of stopping - sometimes temporarily, sometimes permanently - the medicines if the side effects are severe or if the patient or doctor prefers. This is usually not necessary, because medications typically work, though such medications are more expensive than the surgical procedure. In the past, it was common for doctors to recommend surgical removal of the testicles (called orchiectomy) to decrease hormone levels.Your doctor may be able to help prevent some side effects, such as bone loss. The most frequent side effects from hormone therapy include reduced sex drive, impotence, erectile dysfunction, infertility, and bone loss. If these stop working, the drugs abiraterone ( Zytiga), apaleutamide ( Erleada), darolutamide ( Nubeqa), or enzalutamide ( Xtandi) may be effective. Other hormonal treatments include antiandrogens, estrogen- and progesterone-type drugs, and cortisone derivatives.
These drugs reduce testosterone levels to those seen in castrated patients. Several medications can do this, including degarelix ( Firmagon), goserelin ( Zoladex), histrelin ( Vantas), leuprolide ( Eligard, Lupron), relugolix ( Orgovyx), and triptorelin ( Trelstar). That’s why one of the first treatments for advanced prostate cancer is to lower these hormone levels with androgen deprivation therapy. Most prostate cancer grows in response to androgens in the body such as testosterone.There’s no cure for advanced, or metastatic, prostate cancer, but treatments may greatly extend life and ease symptoms. This can be a symptom of early or advanced disease. Prostate cancer can also cause trouble peeing if it has enlarged the prostate. It's an emergency and needs treatment right away. It can cause bladder and bowel problems, trouble walking, and weakness or numbness in your legs.
This happens when the cancer spreads to your spine. Plus, medicines that lower your levels of testosterone and other male sex hormones (which are called androgens) can lead to bone loss and broken bones. Anemia, or a low red blood cell count, can make you feel tired, weak, dizzy, and short of breath. Cancer can affect your bone marrow, which makes red blood cells. It can be a dull ache or sharp and stabbing, and it may feel worse at night. When the cancer moves to your bones, you can have problems like: The bones are a common place for it to spread, and it may show up in your spine, pelvis, or ribs, or the upper part of your thighbone, called the femur. When it goes beyond the tissues next to the prostate gland, it is called metastatic prostate cancer. It may spread to nearby tissues, lymph nodes, bones, or other parts of the body. Prostate cancer is defined as ''advanced'' when it spreads outside the prostate gland.
After looking over these answers, click on other articles in this guide to find in-depth information about treatments, side effects, and other issues that affect you and your family. Here are answers to the most common questions. By taking the time to research your condition, you've taken a good first step. If you just learned that you or a loved one has advanced prostate cancer, you may have many questions and concerns.
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